老化の多様性・恒常性を規定する 　　 解糖系代謝・メタボライトの探索

研究成果

  1. Hiroshi Kondoh and Eiji Hara. Targeting p21 for diabetes: Another choice of senotherapy.
    Cell metabolism 2022 34, 1, p5-7. https://doi.org/10.1016/j.cmet.2021.12.008
  2. Hiroshi Kondoh, Takayuki Teruya, Yung-Ju Chen, Yasuhide Fukuji, Mitsuhiro Yanagida.
    Reply to Zheng et al.: Clinical metabolomics: Detailed analysis by nontargeted method is complementary to large-scale studies. Proc. Natl. Acad. Sci. USA 2022 Feb 1, 119 (5) e2120693119; https://doi.org/10.1073/pnas.2120693119
  3. Hiroshi Kondoh, Takayuki Teruya, Masahiro Kameda, and Mitsuhiro Yanagida.  Decline of ergothioneine in frailty and cognition impairment. FEBS Letters 2022 Jan 28. doi: 10.1002/1873-3468.14299.
  4. Rumi Itoyama, Noriko Yasuda, Fumimasa Kitamura, Tadahito Yasuda, Luke Bu, Xichen Hu, Tomoyuki Uchihara, Kota Arima, Atsuko Yonemura, Keisuke Miyake, Yuya Okamoto, Takahiko Akiyama, Kohei Yamashita, Yosuke Nakao, Toshihiko Yusa, Yuki Kitano, Takaaki Higashi, Tatsunori Miyata, Katsunori Imai, Hiromitsu Hayashi, Yo-ich Yamashita, Takumi Mikawa, Hiroshi Kondoh, Hideo Baba and Takatsugu Ishimoto. Metabolic Shift from Aerobic Glycolysis through 3-PG Accumulation and PHGDH Induction Promotes Tumor Growth in Pancreatic Cancer. Cancer letter 2021 S0304-3835(21)00454-7. doi: 10.1016/j.canlet.2021.09.007.
  5. Masahiro Kameda, Takayuki Teruya, Mitsuhiro Yanagida, and Hiroshi Kondoh. Reduced uremic metabolites are prominent feature of sarcopenia, distinct from antioxidative markers for frailty. Aging 2021 13(17):20915-20934. doi: 10.18632/aging.203498.
  6. Takayuki Teruya, Yung-Ju Chen, Hiroshi Kondoh, Yasuhide Fukuji, Mitsuhiro Yanagida. Whole blood metabolomics of dementia patients reveal classes of disease linked metabolites. Proc. Natl. Acad. Sci. USA 2021 118 (37) e2022857118; https://doi.org/10.1073/pnas.2022857118
  7. Takumi Mikawa, Eri Shibata, Midori Shimada, Ken Ito, Tomiko Ito, Hiroaki Kanda, Keiyo Takubo, Atsuyoshi Shimada, Matilde E Lleonart, Nobuya Inagaki, Masayuki Yokode, and Hiroshi Kondoh. Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis. PLoS One. 2021 16(4): e0250856. https://doi.org/10.1371/journal.pone.0250856
  8. Hiroshi Kondoh, Josep Castellvi, Matilde E. LLeonart. Editorial: How do metabolism, angiogenesis, and hypoxia modulate resistance? Frontiers in Oncology 2021 Apr 12;11:671222. doi: 10.3389/fonc.2021.671222. eCollection 2021.
  9. Masahiro Kameda, Rie Shibata, and Hiroshi Kondoh. Efficient and rapid assessment of multiple aspects of frailty using the Kyoto Frailty Scale, developed from the Edmonton Frail Scale. Journal of Physical Therapy Science 2021 Volume 33 Issue 3 Pages 267-273. https://doi.org/10.1589/jpts.33.267
  10. Hiroshi Kondoh, Masahiro Kameda, and Mitsuhiro Yanagida. Whole Blood Metabolomics in Aging Research. Int. J. Mol. Sci. 2021, 22(1), 175; https://doi.org/10.3390/ijms22010175
  11. Masahiro Kameda, Takayuki Teruya, Mitsuhiro Yanagida, and Hiroshi Kondoh. Reply to Pan et al.: Whole blood metabolome analysis combined with comprehensive frailty assessment. Proc. Natl. Acad. Sci. USA Jan 5, 2021 118;(1) e2016640118; https://doi.org/10.1073/pnas.2016640118
  12. Masahiro Kameda, Takumi Mikawa, Masayuki Yokode, Nobuya Inagaki and Hiroshi Kondoh. Senescence research from historical theory to future clinical application Geriatr Gerontol Int. 28 December 2020 https://doi.org/10.1111/ggi.14121
  13. Jose Alvarez-Meythaler, Yoelsis Garcia-Mayea, Cristina Mir, Hiroshi Kondoh, Matilde E. LLeonart Autophagy Takes Center Stage as a Possible Cancer Hallmark. Frontiers in Oncology 2020 22 October https://doi.org/10.3389/fonc.2020.586069
  14. Hiroshi Kondoh, Takayuki Teruya, and Mitsuhiro Yanagida. Metabolomics of human fasting: New insights about old questions. Open Biology 2020 Sep; 10(9): 200176. doi: 10.1098/rsob.200176
  15. Koji Toriyama, Makoto Kuwahara, Hiroshi Kondoh, Takumi Mikawa, Nobuaki Takemori, Amane Konishi, Toshihiro Yorozuya, Takeshi Yamada, Tomoyoshi Soga, Atsushi, Shiraishi and Masakatsu Yamashita. T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. Communications Biology. 2020 Jul 24;3(1):394. doi: 10.1038/s42003-020-01122-w.
  16. Takumi Mikawa, Eri Shibata, Midori Shimada, Ken Ito, Tomiko Ito, Hiroaki Kanda, Keiyo Takubo, Matilde E Lleonart, Nobuya Inagaki, Masayuki Yokode, and Hiroshi Kondoh Phosphoglycerate mutase cooperates with Chk1 kinase to regulate glycolysis. iScience 2020 Jun 24;23(7):101306. doi: 10.1016/j.isci.2020.101306.
  17. Masahiro Kameda, Takayuki Teruya, Mitsuhiro Yanagida, and Hiroshi Kondoh. Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility. PNAS 2020 Apr 15. pii: 201920795. doi: 10.1073/pnas.1920795117.
  18. Takayuki Teruya, Romanas Chaleckis, Junko Takada, Mitsuhiro Yanagida and Hiroshi Kondoh.
    Diverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood. Scientific Reports 2019 Jan 29;9(1):854.
  19. Lorente J, Velandia C, Leal JA, Garcia-Mayea Y, Lyakhovich A, Kondoh H, LLeonart ME. The interplay between autophagy and tumorigenesis: exploiting autophagy as a means of anticancer therapy. Biol Rev Camb Philos Soc. 2018 93, 1, P152-165
  20. Hiroshi Kondoh, and Mitsuhiro Yanagida. Reply to Makinen VP et al: Small scale but accurate metabolomics with high-reproducibility for identifying age-related blood metabolites PNAS 2016 Jun 21;113(25):E3471-2.
  21. Romanas Chaleckis, Itsuo Murakami, Junko Takada, Hiroshi Kondoh, and Mitsuhiro Yanagida Individual variability in human blood metabolites identifies age-related differences PNAS 2016 113(16): 4252-9.
  22. Taisuke Izumi, Takumi Mikawa, Hiroshi Kondoh, Matilde E LLeonart and Akifumi Takaori-Kondo. The Warburg-like regulation of PGAM in tumor. Trends in Cancer Research 2015　vol10; p103-108
  23. Goodson WH 3rd, et al. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis. 2015 Jun;36 Suppl 1:S254-96.
  24. Amancio Carnero, Carmen Blanco-Aparicio, Hiroshi Kondoh, et al. Disruptive chemicals, senescence and immortality. Carcinogenesis 2015 Jun;36 Suppl 1:S19-37.
  25. Takumi Mikawa, Matilde E LLeonart, Akifumi Takaori-Kondo, Nobuya Inagaki, Masayuki Yokode, and Hiroshi Kondoh Dysregulated glycolysis as an oncogenic event. Cell. Mol. Life Sci. 2015 72:1881-1892
  26. Takumi Mikawa, Koji Okamoto, Matilde E LLeonart, Akifumi Takaori-Kondo, Masayuki Yokode, Nobuya Inagaki , and Hiroshi Kondoh　 Posttranscriptional Regulation of Glycolytic enzyme Phosphoglycerate Mutase. Science Proceedings　2014 1(1) e380;p1-4
  27. T Mikawa, T Maruyama, K Okamoto, H Nakagama, ME LLeonart, T Tsusaka, K Hori, I Murakami, T Izumi , A Takaori-Kondo, M Yokode, G Peters, D Beach, and Hiroshi Kondoh. Senescence-inducing stress promotes proteolysis of glycolytic enzyme phosphoglycerate mutase via ubiquitin ligase Mdm2. Journal of Cell Biology 2014 204(5):729-45.
  28. Romanas Chaleckis, Masahiro Ebe, Tomáš Pluskal, Itsuo Murakami, Hiroshi Kondoh, and Mitsuhiro Yanagida "Unexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites"　 Molecular BioSystems 2014 (10):2538-51.
  29. Itsuo Murakami, Romanas Chaleckis, Tomáš Pluskal, Ken Ito, Kousuke Hori, Masahiro Ebe, Mitsuhiro Yanagida and Hiroshi Kondoh. Metabolism of skin-absorbed resveratrol into its glucuronized form in mouse skin. PLoS One. 2014 9(12): e115359.
  30. Takeshi Tsusaka, Tingting Guo, Teiti Yagura, Toshiaki Inoue, Masayuki Yokode, Nobuya Inagaki, and Hiroshi Kondoh Deacetylation of PGAM in its distinct central region by SIRT2 downregulates its enzymatic activity. Genes to Cells 2014 (10):766-77.
  31. Takumi Mikawa,  Matilde E LLeonart, Akifumi Takaori-Kondo, Masayuki Yokode, and Hiroshi Kondoh RING-mutant Mdm2-M459I Confers Anti-apoptotic Effect in Primary Cells　Journal of Cytology & Histology 2014 5: i103.
  32. Takako Okamoto, Masaki Mandai, Noriomi Matsumura, Ken Yamaguchi, Hiroshi Kondoh, Yasuaki Amano, Tsukasa Baba, Junzo Hamanishi, Kaoru Abiko, Kenzo Kosaka, Susan K, Murphy, Seiichi Mori, Ikuo Konishi. Hepatocyte nuclear factor-1β promotes glucose uptake and glycolytic activity in ovarian clear carcinoma. Molecular carcinogenesis 2015 54(1):35-49.
  33. Andrea Feliciano; Josep Castellvi; Ana Artero-Castro; Josep A Leal; Cleofé Romagosa; Javier Hernández-Losa; Vicente Peg; Angels Fabra; Francisco Vidal; Hiroshi Kondoh; Santiago Ramón y Cajal; Matilde E. Lleonart. miR-125b act as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-<alpha>, CCNJ, and MEGF9. PLoS One. 2013 Oct 3;8(10):e76247.
  34. Okuda J, Niizuma S, Shioi T, Kato T, Inuzuka Y, Kawashima T, Tamaki Y, Kawamoto A, Tanada Y, Iwanaga Y, Narazaki M, Matsuda T, Adachi S, Soga T, Takemura G, Hiroshi Kondoh, Kita T, Kimura T.  Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice. 　PLoS One. 2013 Aug 12;8(8):e72173.
  35. Hiroshi Kondoh, Takumi Mikawa, Matilde E. LLeonart Role of senescence induction in cancer therapy. Aging, Cancer, and Noncancer Pathologies, Vol 1,281-290, 2013.
  36. Venus Sosa, BC; Teresa Moliné, BC; Rosa Somoza, BC; Rosanna Paciucci,; Hiroshi Kondoh,; Matilde E. LLeonart,　 Oxidative stress and cancer: an overview　Ageing Research Reviews　2012　12(1)；p376-390
  37. Kitaoka S, Hiroshi Kondoh, Inoue H. Induced Pluripotent Stem Cell Technology for the Study of Neurodegenerative Diseases. Induced Stem Cells, chapter Ⅴ, Nova Science Publishers Inc, New York, p129-142. 2012
  38. H Kiyokawa, S Muro, T Oguma, S Sato, N Tanabe, T Takahashi, M Kudo, D Kinose, Hiroshi Kondoh, T Kubo, Y Hoshino, E Ogawa, T Hirai , and M Mishima. Impact of COPD exacerbations on osteoporosis assessed by chest CT scan. COPD, 9:1-8, 2012